A high-dimensional linkage analysis model for characterizing crossover interference
نویسندگان
چکیده
منابع مشابه
Statistical analysis of crossover interference using the chi-square model.
The chi-square model (also known as the gamma model with integer shape parameter) for the occurrence of crossovers along a chromosome was first proposed in the 1940's as a description of interference that was mathematically tractable but without biological basis. Recently, the chi-square model has been reintroduced into the literature from a biological perspective. It arises as a result of cert...
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By evolving science, knowledge and technology, new and precise methods for measuring, collecting and recording information have been innovated, which have resulted in the appearance and development of high-dimensional data. The high-dimensional data set, i.e., a data set in which the number of explanatory variables is much larger than the number of observations, cannot be easily analyzed by ...
متن کاملCrossover interference
What is crossover interference? During prophase of meiosis in most eukaryotes, DNA recombination events between homologous chromosomes are induced to occur at high frequency, so there are usually multiple events per chromosome pair per meiosis. Whereas many of these recombination events are non-reciprocal, a subset results in reciprocal exchange of genetic material between chromosomes — crossov...
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We propose a new method for calculating probabilities for pedigree genetic data that incorporates crossover interference using the chi-square models. Applications include relationship inference, genetic map construction, and linkage analysis. The method is based on importance sampling of unobserved inheritance patterns conditional on the observed genotype data and takes advantage of fast algori...
متن کاملIncorporating interference into linkage analysis for experimental crosses.
The phenomenon of interference in genetic recombination is well-known and studied in a wide variety of organisms. Multilocus linkage analysis, which makes use of recombination patterns among all genetic markers simultaneously, is routinely used with data on humans and experimental organisms to build genetic maps. It is also used to try to determine the genes involved in traits of interest, such...
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ژورنال
عنوان ژورنال: Briefings in Bioinformatics
سال: 2016
ISSN: 1467-5463,1477-4054
DOI: 10.1093/bib/bbw033